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The Systems Approach to Aerosol Drug Delivery

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 SARS Proposal

Out of concern for the public health, Healthline Medical would like to propose the use of its

Medicator +Plus® Aerosol Maximizer

as a potential safeguard against the spread of Severe Acute Respiratory Syndrome (SARS) by aerosol droplets generated during nebulizer therapy.  We advocate the use of absolute filtered aerosol drug delivery during therapy in highly infectious lung diseases and when using aerosols to which caregivers should not be exposed.  

Photo: Medicator+Plus Aerosol Maximizer aerosol drug delivery system showing the manifold, 1 liter reservoir bag, small volume nebulizer and exhalation filter.  Note the noseclips -- additional protection against environmental contamination by small volume nebulizer aerosol particles.  Mask setup also available.

The basis for this caution can be found in the April 7, 2003 report in the New England Journal of Medicine by Lee, et al, entitled "A Major Outbreak of Severe Acute Respiratory Syndrome in Hong Kong:"  

Current SARS News & Resources
Abstract on NEJM Web Site  
Full Article in Adobe Acrobat PDF Format

Quote from the report in New England Journal of Medicine:

"We suspected that the infection was transmitted by droplets and possibly by fomites, and we therefore instituted both airborne precautions (e.g., use of the N-95 respirator) and contact precautions (e.g., use of gowns and gloves), as recommended by the CDC.  However, the use of a jet nebulizer to administer aerosolized albuterol in the index patient had probably aggravated the spread of the disease by droplet infections."

Eliminate environmental contamination.
The Medicator+Plus® completely eliminates
environmental contamination during nebulizer therapy through its built-in capability to effectively filter the exhalation port to eliminate therapist exposure to patient-exhaled aerosol particles.  The system can use any nebulizer or any respiratory filter of your choosing or you can pick from the choices we offer.  The simple-to-use system can be used for adults and children, including infants.  A Convenience Kit adapter maintains high efficiency even with an extension tubing for mouthpiece or mask.

Use in the Emergency Department.
We recommend considering
the Medicator+Plus® for bronchodilator therapy in the Emergency Department and other areas of the hospital or clinic where respiratory patients may be treated for the first time without knowledge of their history, or in patients presenting with respiratory symptoms who have recently traveled abroad.  The use of this device will provide a much greater margin of safety than conventional unprotected aerosol therapy.

While there is no conclusive evidence to suggest that SARS is spread by small volume nebulizer treatments, or that our device or any other device will mitigate the transmission of SARS virus, we propose our device because of the following features/benefits:

Environmental contamination is eliminated through the use of a patented manifold and diaphragm/reservoir bag system and the capability to effectively filter the exhalation port.
Reservoir bag captures and stores aerosol that is generated during the patient's exhalation phase and allows it to be inhaled during the subsequent breath, thereby completely eliminating atmospheric "dumping" of aerosol typical of most small volume nebulizer systems
Patented system dramatically increases the efficiency of virtually any commercial nebulizer.  This device so vastly improves aerosol drug delivery (by a factor of 2-3 times) that it essentially cuts breathing time in half or more by retaining and using aerosolized medication that would have been wasted with a standard nebulizer/tee system.  This means that treatments can be completed more quickly.  
The Medicator+Plus may also be an ideal aerosol drug delivery system for nebulized antiviral therapy should such agents become available because it minimizes environmental contamination, costly drug waste and dosing "guesswork," due to its reliable, repeatable doses. 

Three variations of the Medicator+Plus® (Cat. Nos. AM-602, AM-602A, or AM-603) are described in the Products section of this web site.  

 


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